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TABLE OF CONTENT:
CHAPTER ONE
INTRODUCTION
1.1
Background of the Study
1.2
Statement of the Research Problem
1.3
Objectives of the Study
1.4
Significance of the Study
1.5
Research Questions
1.6
Research Hypothesis
1.7
Conceptual and Operational Definition
1.8
Assumptions
1.9
Limitations of the Study
CHAPTER TWO
LITERATURE REVIEW
2.1
Sources of Literature
2.2
The Review
2.3
Summary of Literature Review
CHAPTER THREE
RESEARCH METHODOLOGY
3.1
Research Method
3.2
Research Design
3.3
Research Sample
3.4
Measuring Instrument
3.5
Data Collection
3.6
Data Analysis
3.7
Expected Result
CHAPTER FOUR
DATA ANALYSIS AND RESULTS
4.1
Data Analysis
4.2
Results
4.3
Discussion
CHAPTER FIVE
SUMMARY AND RECOMMENDATIONS
5.1
Summary
5.2
Recommendations for Further Study
Bibliography
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CHAPTER
ONE
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INTRODUCTION
Intake
of tomato and tomato based-products contributes to the absorption of a wide
range of carotenoids in human serum and tissues. The prominent carotenoid in
tomatoes is lycopene, a pigment principally responsible for the deep-red
colour of tomato fruits and tomato products. Fruits and vegetables contain in
excess of 40 carotenoids that are routinely absorbed and metabolized by
humans (Khachik, 1992).
Tomatoes
and tomato products are now being investigated for their potential role in
prostate cancer prevention and therapy. This review summarizes the in vitro
and invivo evidence as well as the molecular data that show the
anticarcinogenic potential of tomatoes.
Raw and processed tomatoes are among the most commonly consumed
vegetables. They are rich in the phytochemicals, carotenoids and polyphenols.
Lycopene and quercetin are the most abundant carotenoids and flavonols
respectively. Canned tomato sauce is the primary source of lycopene whereas
the tomato skin is enriched with flavonols. Most epidemiological studies
suggest that the consumption of tomatoes and the products in associated with
a reduced prostate cancer risk. The health professionals follows-up study
found that men who consumed 2 to 4 servings of raw tomatoes per week had a
more than 20% reduction in prostate cancer risk compared to men who did not
consume tomatoes. High lycopene plasma concentrations were associated with a
low incidence of prostate cancer and aggressive prostate cancer in rested
case-control study with the physician’s health study. Invitro data show that
the compounds found in tomatoes are potent anticarcinogens. Cancer cell
growth is inhibited by the polyphenols quercetin, kaempferol and naringerin
in a dose dependent manner. These compounds do not have cytotoxic effect. In a
rat model of prostate cancer, tomato powder into but not lycopene intake by
itself reduced prostate cancer related mortality. This suggests that the
compounds in tomatoes have an additive influence on prostate cancer.
Lycopenes exist as either the cis or trans isomer. The half-life of lycopene
is approximately 10 to 14 days, so it remains in the body during washout
period. The trans isomer dominates in tomatoes, between the cis isomer
dominates in serum and tissues and during a washout period. Thus, recent intake
of lycopenes is reflected in blood concentrations whereas long-term exposure
is determined in the tissues.
Lycopene
is a bioactive carotenoid found in many red fruits and vegetables, such as
tomatoes, watermelon, pink grapefruits etc. Different fruits, vegetable and
their products contain different concentrations of lycopene. This natural red
pigment is synthesized exclusive by plants and microorganisms (fungi,
bacteria and algae). It facilitates the absorption of light during
photosynthesis and also provides protection against photosensitization (Adam
et al., 1996) Animals including human being, cannot synthesize lycopene
therefore, they obtain lycopene exclusively from diet (Tapiero et al. 2004;
Omoni and Aluko, 2005).
Although,
tomato contain a lower concentration of nutrients compared to other
commercially grow fruits species, they are a major source of lycopene.
Lycopene comprises 83% of the total pigment present in tomatoes (Shi et al.,
1990). Therefore, the amount of lycopene present in tomatoes other fruits and
vegetables vary with variety, degree of ripeness and other dimatic conditions
and agricultural practices.
The
fraction of vitamin C in the diet that is absorbed and the rate at which the
excess is eliminated from the body vary strongly with the dose. Large,
randomized clinical trials on the effects of high doses on the general
population have not been conducted. Venturi suggested that the antioxidant
action of ascorbic acid developed first in the plant kingdom when, about 500
million years ago (mya), plants began to adapt to antioxidant mineral
deficient fresh waters of estuaries. Ascorbic acid or vitamin C is a common
enzymatic cofactor in mammals used in the synthesis of collagen. Ascorbate is
a powerful reducing agent capable of rapidly scavenging a number of reactive
oxygen species (ROS). Freshwater fishes also require dietary vitamin C in
their diet or they will get scurvy. The most widely recognized symptoms of
vitamin C deficiency in fishes are scoliosis, lordosis and dark skin coloration.
The
name “carotene” was first coined in the early 19th century by the
scientist Wachenroder after he crystallized this compound from carrot roots.
Beta-carotene is a member of the carotenoids, which are highly pigmented
(red, orange, yellow), fat-soluble compounds naturally present in many
fruits, grains, oils and vegetables (green plants, carrots, sweet potatoes,
squash, spinach, apricots, and green peppers). Alpha, beta and gamma carotene
are considered provitamins because they can be converted to active vitamin A.
The carotenes possess antioxidant properties. Vitamin A serves several
biological functions including involvement in the synthesis of certain
glycoproteins. Commercially available beta-carotene produced synthetically or
from palm oil, algae, or fungi. Beta-carotene is converted to retinol, which
is essential for vision and is subsequently converted to retinoic acid, which
is used for processes involving growth and cell differentiation
Objectives of the study
The
main objective of this project is to do a comparative analysis (quantitative
analysis) on phytochemicals present in tomatoes and some selected tomato
products (canned tomato) sold in any common market in Nigeria.
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